Anti-WHSC2 antibody Catalog Number：OM642659

Product Profile

Product Name

Anti-WHSC2 antibody

Antibody Type

Primary Antibodies

Immunogen

Polypeptide

Key Feature

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Applications

ELISAIHCWB

WB:1:200-1:2000
IHC:1:200-1:2000

Species Reactivity

HumanMouseRat

Concentration

1mg/ml

Purification

Protein A

Target Information

Gene Symbol

NELFA

Gene Synonyms

WHSC2
NELF-A
P/OKcl.15

Gene Full Name

negative elongation factor complex member A

Gene Summary

More

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, ａnd may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted ａnd tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]

Molecular Weight(MW)

57KD

Cellular Localization

Nucleus

Application

WB

• Western blot analysis using WHSC2 antibody against A549(1) cell lysate.

IHC

• Immunohistochemical analysis of paraffin-em
• bedded bladder cancer tissues using WHSC2 antibody with DAB staining.

IHC

• Immunohistochemical analysis of paraffin-em
• bedded esophageal cancer tissues using WHSC2 antibody with DAB staining.

Application Notes

WB:1:200-1:2000
IHC:1:200-1:2000

Additional Information

Form

Liquid

Storage Instructions

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Storage Buffer

Purified antibody in PBS with 0.05% sodium azide.