欧盟评估大肠杆菌CCTCC M 2024477生产的L-苏氨酸作为所有动物饲料添加剂的安全性和有效性

核心提示：2025年10月15日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组就大肠杆菌CCTCC M 2024477生产的L-苏氨酸（L‐threonine）作为所有动物饲料添加剂的安全性和有效性发表科学意见。……（世界食品网-www.shijieshipin.com）

　　 2025年10月15日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组就大肠杆菌CCTCC M 2024477生产的L-苏氨酸（L‐threonine）作为所有动物饲料添加剂的安全性和有效性发表科学意见。
　　经过评估，专家小组认为在建议的使用条件下该添加剂对目标物种、消费者和环境是安全的。评估中的添加剂被认为是非反刍动物物种氨基酸L-苏氨酸的有效来源。为了使补充的L-苏氨酸对反刍动物和非反刍动物同样有效，需要防止其在瘤胃中降解。部分原文报道如下：

　　Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l-threonine produced by fermentation with Escherichia coli CCTCC M 2024477 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain is genetically modified. None of the genetic modifications raised a safety concern. Viable cells or DNA of the production strain were not detected in the final product. The use of l-threonine produced with E. coli CCTCC M 2024477 in feed is safe for the target species when supplemented in appropriate amounts to the diet according to their nutritional needs. The FEEDAP Panel has concerns on the use of amino acids in water for drinking. The use of l-threonine (≥ 98.0%) produced with E. coli CCTCC M 2024477 in animal nutrition is considered safe for the consumers and the environment. Regarding the user safety, the FEEDAP Panel cannot conclude on the potential of the additive to be irritant to skin and/or eyes and to be a potential skin sensitiser. The FEEDAP Panel considers that the exposure of the users to bacterial endotoxins should be minimised. Any exposure to the additive is a risk. The additive is regarded as an effective source of the amino acid l-threonine for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.