日本批准新的基于干细胞的阿尔茨海默病疗法

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标签：#cell therapy

这可能是阿尔茨海默氏症治疗的一个重大突破，日本厚生省为一种基于静脉注射脂肪来源干细胞并将其植入脊髓的再生医学技术开了绿灯。

In what could be a major breakthrough for Alzheimer's treatment, the Japanese Ministry of Health and Welfare has given the greenlight to a regenerative medicine technology based on administering fat-derived stem cells intravenously and into the spinal cord.

这种新的干细胞疗法由韩国领先的成人干细胞研究机构Biostar干细胞研究所开发，包括静脉注射1.5亿至2.5亿个干细胞，然后每隔两到四周向脊髓腔注射5次5000万个干细胞。

Developed by Korea's leading adult stem cell research institute, Biostar Stem Cell Research Institute, this new stem cell therapy involves administering 150-250 million stem cells intravenously and a further 50 million into the spinal cord cavity five times at intervals of two to four weeks.

Biostar干细胞研究所所长Jeong Chan-Ra博士说：“这是我们战胜阿尔茨海默氏症项目的第一步，该项目是在我们致力于战胜这种疾病的基础上启动的。”

“This is the first step in our project to overcome Alzheimer’s, which was launched with our commitment to conquer this disease,” Biostar Stem Cell Research Institute director Dr. Jeong-Chan Ra said.

“随着干细胞治疗的开始，Biostar将支持来自世界各地的阿尔茨海默病患者——包括日本、韩国、中国和美国，从日本开始——恢复他们的记忆，最终恢复他们的人性。”

“With the start of stem cell treatment, Biostar will support Alzheimer’s patients from all over the world – including Japan, Korea, China, and the US, starting in Japan – to restore their memory and ultimately their humanity.”

全球每年有超过1000万例新的痴呆症病例，阿尔茨海默氏症是这种神经退行性疾病最常见的病因。

There are over 10 million new cases of dementia each year globally, with Alzheimer’s being the most common cause of the neurodegenerative disease.

基本治愈

Fundamental cure

与大多数仅限于减缓疾病进展的阿尔茨海默病治疗方法不同，干细胞疗法有望提供一种功能性治疗方法。

Unlike most treatments for Alzheimer’s, which are limited to slowing the progression of disease, stem cell therapies are expected to offer a functional cure.

对小鼠模型的测试表明，干细胞疗法提供了一种多管齐下的治疗阿尔茨海默氏症的途径。

Testing on mice models revealed stem cell therapies offer a multi-pronged path of attack against Alzheimer's.

接受干细胞治疗的小鼠在重要方面得到了改善——脑血管再生、脑细胞保护和再生都在治疗后得到了观察，这也介导了IL-10细胞因子。

Mice who received the stem cell treatment improved in vital ways – cerebral vascular regeneration, and brain cell protection and regeneration were all observed following treatment, which also mediated the IL-10 cytokine.

IL-10在炎症和神经保护反应中起着核心作用，尤其是在炎症被认为是认知能力下降的核心因素之一的情况下。

IL-10 plays a central role in inflammation and neurological protection responses, particularly relevant given inflammation is considered to be one of the core contributors to cognitive decline.

亚太地区医疗保健和生物科学行业的媒体平台BioSpectrum Bureau的一篇文章指出：“从未有其他化合物或治疗方法如此强烈地表明有潜力预防和阻止这种席卷患者及其家人的不治之症痴呆症的流行。”

An article by the BioSpectrum Bureau, a media platform for the healthcare and bioscience industry in the Asia Pacific region, stated: “No other compound or treatment has ever suggested so strongly the potential to prevent, as well as stop, this epidemic of incurable dementia sweeping across suffering patients and their families.”

东京新宿诊所已经开始接受治疗，为阿尔茨海默氏症患者提供了急需的治疗途径。

Treatment has already begun at the Shinjuku Clinic in Tokyo, providing a sorely needed treatment pathway for those suffering from Alzheimer's.

本文来源于网络资料，由【情报强企】整理