CD59 Antibody (R-79) Catalog Number：OM197298

Product Profile

Product Name

CD59 Antibody (R-79)

Antibody Type

Primary Antibodies

Modification Notes

CD59 is a GPI-anchored glycoprotein that is expressed on leukocytes, vascular endothelial cells, various epithelial cells ａnd placenta. CD59 acts together with CD58 in mediating T cell adhesion ａnd activation, ａnd it may be a second ligand of CD2. CD59 functions as a regulator of the terminal pathway of complement by binding to the C8/C9 components of the assembling membrane attack complex (MAC) on host cell membranes, to s the formation of the lytic pore. CD59 also drives both calcium release ａnd activation of lipid-raft associated signalling molecules such as tyrosine kinases. CD59 gene has two p53-responsive domains that may be implicated in the defense of host cells from damage by the complement system in inflammation, suggesting that p53 could be used to mediate susceptibility of tumor cells to the complement lysis during chemotherapy.

Key Feature

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Applications

WBIPIFELISA

recommended for detection of CD59 of mouse ａnd rat origin by WB, IP, IF ａnd ELISA:

Species Reactivity

HumanMouseRat

Concentration

1mg/ml

Purification

Affinity purified

Target Information

Alternative Names

epie corresponding to amino acids 23-101 representing mature CD59 of rat origin

Tissue Specificity

epie corresponding to amino acids 23-101 representing mature CD59 of rat origin

Database Links

Entrez Gene

Application

Application

• Western blot analysis of CD59 expression in rat brain tissue extract.

Application Notes

recommended for detection of CD59 of mouse ａnd rat origin by WB, IP, IF ａnd ELISA:

Additional Information

Form

Liquid

Storage Instructions

For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Storage Buffer

phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.