第二届Aggregate X Angewandte Forum正在直播中！主编携六位嘉宾分享前沿成果

“第五届聚集诱导发光国际研讨会”（AIE5）将于2022年8月12日-14日在深圳召开。此次会议由唐本忠院士、刘斌院士、Andrea Pucci教授、秦安军教授联合担任主席，由香港中文大学（深圳）、深圳市分子聚集体功能材料重点实验室、深圳分子聚集体科学与工程研究院、广东省大湾区华南理工大学聚集诱导发光高等研究院联合举办。“聚集诱导发光国际研讨会”为两年一度的国际学术盛会，前四届会议分别在武汉、广州、新加坡、澳大利亚阿德莱德成功举办。AggregateX Angewandte Forum首次亮相于2021年7月广州举行的“聚集体科学国际研讨会暨聚集诱导发光研究20周年”会议。

Aggregate X Angewandte Forum将再次与大家见面！2022年8月14日上午，第二届AggregateX Angewandte Forum将在“第五届聚集诱导发光国际研讨会”中举行。论坛将邀请唐智勇、毛宗万、蒋兴宇、田阳、韩达、李光琴六位教授作为特邀嘉宾到场，与化学领域学者交流沟通，并分享前沿学术成果。

本次论坛将通过直播平台实时与大众交流，报名将于今日开启，欢迎踊跃参与！

会议时间

2022年8月14日 8:30 - 12:10

扫描二维码，直接观看

https://gcb.h5.xeknow.com/s/1UtvNq

会议日程

时间

主讲嘉宾

报告题目

8:30-8:45

Opening Speech，唐本忠

8:45-9:15

唐智勇

Biomimetic Chiral Photonic Crystals

9:15-9:45

毛宗万

Chemical Biology of Organic AIEgens and Their Metal Complexes

9:45-10:15

蒋兴宇

Biological and Biochemical Advances of AIEgen Nanomaterials

10:15-10:30

Break

10:30-11:00

田阳

Mechanism and Applications of Multicolor Carbon Dots with Improved Fluorescence Quantum Yield

11:00-11:30

韩达

DNA-Based Computation for Molecular Diagnostics

11:30-12:00

李光琴

MOF-Based Materials for Hydrogen Production and Conversion

12:00-12:10

Closing Speech，苏鑫

主讲人及报告简介

唐智勇

国家纳米科学中心

唐智勇，国家纳米科学中心研究员，博士生导师，国家纳米科学中心副主任，基金委创新群体负责人，科技部纳米重大研究计划首席科学家。武汉大学获学士、硕士学位，中国科学院长春应用化学研究所获博士学位，瑞士苏黎世联邦高等工业学院、密歇根大学从事博士后工作，后任职于国家纳米科学中心。主要研究无机纳米材料的制备、组装及其在能源和催化领域的应用。获国家杰出青年科学基金资助、并先后入选新世纪百千万人才工程国家级人选，中国科学院“杰出青年”、2018年获国家自然科学奖二等奖（第一完成人）。

报告题目：

Biomimetic Chiral Photonic Crystals

The amazing iridescent colors from the cuticle of beetles are known to originate from their intricate nanoscale organization of bio-fibers, artificial inorganic materials with comparable optical response. In past years, we developed a general method to fabricate biomimetic chiral photonic crystals via Langmuir-Schaefer assembly of colloidal inorganic nanowires. We not only reproduce the intricate helical structure and circularly polarized color reflection in beetles, but also acquire the highest chiroptical activity with a dissymmetry factor of -1.6 among the chiral inorganic nanostructures. More importantly, beyond nature, programmable structural control based on the precise interlayer arrangement endows us an unprecedented freedom to manipulate the optical activity of as-fabricated chiral photonic crystals, for instance, strong chiral photoluminescence and laser could be also realized.

毛宗万

中山大学

毛宗万，中山大学化学学院教授，博士生导师，国家杰出青年科学基金获得者。主要从事金属酶化学、金属药物化学、分子探针、核酸化学生物学等研究，主持教育部创新团队、科技部973课题、国家基金重点等项目，近年来在Natl. Sci. Rev.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nat. Commun.等杂志上发表论文230余篇，获授权发明专利9件，出版专著教材4部，获国家自然科学二等奖、广东省自然科学一等奖等多项科技奖励。

报告题目：

Chemical Biology of Organic AIEgens and Their Metal Complexes

Organic photosensitizers of aggregation-induced emission (AIEgens) have attracted increasing attention in tumor treatment because they can be designed to produce strong fluorescence and efficient ROS in combination with metal ions and biomacromolecules. Recently, we studied a series of chemical biology of antitumor fluorescence and phosphorescence complexes. On the one hand, we designed novel triphenylamine and other derivatives for recognition, detection and regulation of G4-DNA in live cells. We identified multiple G4 aggregate structures, proposed a new kinetic control targeting strategy, developed a new method of visualization and digital detection of G4 in live cells as well as G4 targeted photodynamic therapy. In addition, we detected the liquid-liquid phase separation of DNA in live cells, and the cell morphology changes in cell iron death with DNA photo-switch complexes and cyanine dye, respectively. On the other hand, we extensively investigated the antitumor effects and combination therapy of phosphorescence organometallic compounds in vitro and in vivo. Through hybridization of metal with ligand and antibodies, we realized molecular targeting of tumor cells, metabolic and homeostatic intervention and immune regulation , and further revealed fine structural changes in cellular biological processes through a variety of fluorescence imaging techniques. Our work provides novel strategies for the development of metal-based AIEgens in tumor therapy and bioprobing.

蒋兴宇

南方科技大学

蒋兴宇，南方科技大学讲席教授，生物医学工程系系主任。1999年获芝加哥大学学士，2004年获哈佛大学博士，2005年开始在中科院（国家纳米科学中心）工作，2018 年调入南方科技大学任讲席教授，2010年获 “国家杰出青年科学基金”。曾获国务院政府特殊津贴、科技部“创新人才推进计划”、科技部重点研发计划（首席科学家）、基金委重点项目等。是英国皇家化学会(RSC)和美国医学与生物工程学院(AIMBE)会士，曾获腾讯“科学探索奖”、中国化学会青年化学奖等。发表论文300多篇。研究方向主要包括：微流控和纳米生物医学。

报告题目：

Biological and Biochemical Advances of AIEgen Nanomaterials

Our work integrates microfluidics and aggregation-induced emission luminogens (AIEgens). In our recent works, we have demonstrated the interdisciplinary explorations of AIEgens by incorporating microfluidics and point-of-care (POC) techniques. Our rationally designed microfluidic chip achieves to assemble sub-10 nm AIEgen quantum dots. Compared to traditional AIEgen dots (>25 nm), AIE QDs achieve more efficient cell labeling without surface modification with membrane-penetrating peptides, and significantly higher contrast at the solid tumor and more efficient evasion from the liver. In another effort We used AIEgen as the organic ligand to synthesize bright fluorescent MOFs, i.e., MAFs, to develop an ultrasensitive and stable POC hydrogel sensor (Figure 1B). Compared to traditional QDs and fluorophores, MAFs-based POC sensors have 2 ~ 3 orders of magnitude enhanced sensitivity.

田阳

华东师范大学

田阳，华东师范大学教授，化学与分子工程学院院长。1989年毕业于北京航空航天大学获学士学位，2000年于日本东京工业大学获得博士学位，2003年在东京大学从事博士后研究，2005年加入同济大学化学系任教授。2013年加入华东师范大学，现为化学与分子工程学院院长。田阳团队长期从事活体脑电信号的化学表达分析领域研究，在发展脑神经化学分子的精准分析测量策略、建立长时程稳定的高空间分辨脑成像方法、及开拓高速成像分析新仪器等方面开展了深入和系统的工作，对神经分析和脑成像领域做出了重要贡献。迄今共发表论文160余篇，包括Sci. Adv.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Anal. Chem.等。所有论文他引11380次，2019年入选Elsevier中国高被引学者；申请中国发明专利12项，授权8项；受邀撰写为系列神经化学分析工具类英文丛书撰写章节。曾获国家杰出青年基金资助，入选国家万人计划科技创新领军人才；获日本化学会“The distinguished lectureship award”，中国分析测试协会一等奖(第一)，中国化学会女分析化学家，上海市自然科学奖一等奖(第一) ；受邀在神经学和神经科学等国际国内做大会、主题或邀请报告30余次。目前担任ChemComm副主编和《高等化学学报》副主编。

报告题目：

Mechanism and Applications of Multicolor Carbon Dots with Improved Fluorescence Quantum Yield

Understanding the intrinsic luminescence mechanism of carbon dots (CDs) is the key issue to improve their performance and expand the applications. CDs have attracted broad interests due to their diverse and favorable properties like good biocompatibility and water-solublility with abundant functional groups. However, the relatively low quantum yield (QY) of CDs limits their further applications. Although several strategies were proposed to enhance QY of CDs, such as dopping strong Lewis acids, introducing heteroatoms or controlling the oxidation degree of surface groups, the improvement of QY was still not significant because of the unclear luminescence mechanism.

Herein, three CDs were synthesized from precursors of o-phenylenediamine, m-phenylenediamine, and p-phenylenediamine, named as oCD, mCD and pCD. These CDs displayed similar size of 2.31±0.16 nm with lattice spacing of 0.21 nm, functionalized with -OH, -NH₂/-NH-, C=O/C=N, and C-O groups. By systematical investigation the luminescence mechanism of CDs, it was discovered that the prepared CDs contained multi-emissive centers related to intrinsic state, shallow defective state and surface state. It was discovered that electron transfer from intrinsic state to surface state was regulated by hydrogen bonding (HB). Moreover, HB was found to suppress the emission of surface-state in CDs by generating non-radiative transition pathways. Based on understanding of fluorescence mechanism of CDs, the QYs of oCD, mCD, and pCD were improved to 60.0±3.0%, 47.9±2.5% and 41.2±3.0%, respectively. Benefiting from the high stability and multi-emission properties of CDs, functionalized CDs were achieved white light emission with fluorescence stability for at least 6 months. On the other hand, due to the improved QY of CDs, they were successfully applied to super-resolution fluorescence imaging in mitochondria and endoplasmic reticulum (ER). It was first found that mitochondria were enclosed by ER. Moreover, taking advantages of the developed CDs with large two-photon absorption cross section and good biocompatibility, the functionalized oCD was first employed for optogenetic regulation in deep brain regions, which caused significant movement in mice with back and forth in the experimental areas under the stimulation of 880 nm light.

韩达

中科院基础医学与

肿瘤研究所

韩达，中科院基础医学与肿瘤研究所研究员，上海交通大学医学院分子医学研究院研究员。主要研究方向为临床生物分析，以复杂生物体系中的蛋白、核酸等重要生物大分子靶标作为研究对象，发展了基于核酸分子计算的测量分析原理与方法，力求解决复杂样本中分子靶标检测灵敏度差、选择性识别难、信号读取复杂度高、检测分子信息与临床诊断相关度低等共性难点问题，为医学诊断、化学和生物学研究提供研究理论、方法及技术。以第一或通讯作者在Science、Nature Nanotechnol.、Nature Chem.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等期刊发表论文，获得中国化学会青年化学奖等奖励。

报告题目：

DNA-Based Computation for Molecular Diagnostics

Battling diseases has been a never-ending task in human history. Current studies reveal that many diseases are characterized by abnormal behavior on the molecular level, such as deviant gene expression. The key to the successful treatment of these disease is the development of intelligent diagnostic tools that can rapidly and accurately identify and report the complex changes at molecular level. DNA-based computation has been demonstrated to be a promising platform for intelligent nanotechnological and biomedical applications due to its ability on recognizing molecules and processing information in a programmable way. However, rationally designed DNA computation systems have seldom been employed in diagnostic applications, where the integration of multiple biomarker recognition and logical information processing is most needed, especially in biological samples towards clinical applications, with only a few examples in classifying diseases in synthetic samples mimicking practical analyte composition. The difficulties are mainly originated from highly complicated environment in biological samples such as low analyte concentrations and high background interferences. In addition, there is still lack of powerful DNA computation scheme with good diagnostic accuracy that are compatible with current point of care settings in clinics. Towards these challenges, we developed a DNA-based computational platform that analyzes complex biomarker profile (e.g. miRNA, mRNA, and genetic DNA) directly in clinical samples and rapidly produces diagnostic results for different diseases (e.g. cancers and infection-related diseases) without human intervention and complicated instrumentation. We hope that our DNA-based computational platform can be further expanded for clinical molecular diagnostics and will inspire more work on utilizing the power of DNA computing towards accurate, rapid, low-cost, and non-invasive disease screening and classification.

李光琴

中山大学

李光琴，中山大学教授，博士生导师，国家海外引进高层次青年人才、广东省“珠江人才计划”引进创新创业团队带头人，一直致力于多孔功能材料的合成与氢能研究，主要包括：多孔配位聚合物基复合材料的合成及其在制氢、储氢和加氢催化方面的应用。在Nat. Mater.、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem.、Adv. Mater.、CCS Chem.、Adv. Energy Mater.等高水平国际期刊发表SCI论文30多篇，其中高被引4篇；已申请专利10余件。主持国家海外高层次人才项目、国家自然科学基金委面上项目、科技部重点研发计划课题、广东省“珠江人才计划”引进团队项目等。曾多次获得国内外重要学术奖项包括日本学术振兴会JSPS育志奖、京都府知事奖、日本配位化学会青年奖、中山大学芙兰奖教金、优秀研究生导师奖、物理化学奖等。担任Energy & Environmental Materials （EEM）、Chinese ChemicalLetters （CCL）等期刊青年编委。任中国留日同学会理事、广东省科协第九次代表大会代表、广东省科技人才发展研究会会员、广东省欧美同学会理事、中国可再生能源协会青年委员、中国颗粒学会功能材料与界面科学专业委员等。

报告题目：

MOF-Based Materials for Hydrogen Production and Conversion

As a clean, high-energy and renewable fuel, hydrogen gas increasingly attracts public concern due to its potential for solving the environment-related issues which caused by the consumption of fossil fuels. It’s worth noting that the adsorption and desorption processes of different species are all involved in the hydrogen production and hydrogenation catalysis, so the effective regulation of catalytic sites is of great importance. Nowadays, metal-organic framework (MOF) materials with clearly and tunable structure, has become the most promising model catalyst for design and research at the molecular level.

Our group proposed the electronic regulation strategy of MOF catalysts via the structral design and synthesis for hydrogen production and hydrogenation, then clarify the catalytic mechanism and structure-activity relationship through advanced characterization techniques. For instance, modulating the electronic structure of metal center in the MOF by the introduce of Ru single-atom, leading to the optimization of adsorption energy for H₂O and H*, and the enhancement of HER performance; adjusting the band gap and charge distribution of MOF by introducing different missing linkers, so as to optimize the adsorption energy of reaction intermediates thus improve the OER performance; turning the coordination environment of Zn²⁺ center, thus changing the intermediate adsorption and contributing to the high selectivity towards 2 e⁻ oxygen reduction to hydrogen peroxide; achieving highly-selective hydrogenation of α,β -unsaturated aldehydes by regulating the substrate adsorption mode through MOF. These related works provide new insights for the development of hydrogen-producing/hydrogenation catalysts.