本文由专注营养科普的微信公众平台《极养视界》公众号:JiYang_Vision授权转载。
中国临床营养网(lcyycc)
姜黄素“发声”:你的肠道,我来守护!
撰写|Jieyao YuanPhD candidate
校稿|HaoranPHD 编审|XinyinPHD, RD
编辑|Yuan Ye设计|Fay
引言姜黄素在学术界因其生物利用率低而使得它的临床价值饱受争议。在人们研究提高姜黄素利用率的同时,它的另一作用——对肠道健康的影响,也渐渐浮出水面。那么它对肠道健康的贡献到底在哪里呢?
文章纲要
- 生物利用率不高,姜黄素的困境
- 姜黄素对肠道健康的调节-姜黄素对微生物菌群的影响 -姜黄素对肠道通透性的影响 -姜黄素抗炎、抗菌、抗过敏
- 极养君点评
1
2
3
参考文献
[1] Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol 2017;174:1325–48.
[2] Metzler M, Pfeiffer E, Schulz SI, Dempe JS. Curcumin uptake and metabolism. Biofactors 2013;39:14–20.
[3] Logan AC, Jacka FN, Prescott SL. Immune-microbiota interactions: dysbiosis as a global health issue. Curr Allergy Asthma Rep 2016; 16:13.
[4] Dinan TG, Cryan JF. The microbiome-gut-brain axis in health and disease. Gastroenterol Clin North Am 2017;46:77–89.
[5] Feng W, Wang H, Zhang P, Gao C, Tao J, Ge Z, Zhu D, Bi Y. Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats. Biochim Biophys Acta 2017;1861:1801–12.
[6] Bereswill S, Munoz M, Fischer A, Plickert R, Haag LM, Otto B, Kuhl AA, Loddenkemper C, Gobel UB, Heimesaat MM. Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS One 2010;5:e15099.
[7] Wang N,Wang G, Hao J, Ma J, Wang Y, Jiang X, Jiang H. Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal
epithelial cells. Dig Dis Sci 2012;57:1792–801.
[8] Kim CY. Inhibition of interleukin-1α-induced intestinal epithelial tight junction permeability by curcumin treatment in Caco-2 Cells in Caco-2 cells. J Life Sci 2016;26:1082–7.
[9] Ghosh SS, Bie J, Wang J, Ghosh S. Oral supplementation with non-absorbable antibiotics or curcumin attenuates Western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice-role of intestinal permeability and macrophage activation. PLoS One 2014;9:e108577.
[10] Lopresti AL. The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects? Adv Nutr. 2018 Jan 1;9(1):41-50.
[11] Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. J Surg Res 2000;89:169–75.
[12] Okudan N, Belviranli M,Gokbel H, Oz M, Kumak A. Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury. Phytomedicine 2013;20:844–8.
[13] Khonche A, Biglarian O, Panahi Y, Valizadegan G, Soflaei SS, GhamarchehrehME,MajeedM, Sahebkar A. Adjunctive therapy with curcumin for peptic ulcer: a randomized controlled trial. Drug Res (Stuttg) 2016;66:444–8.
[14] Gul P, Bakht J. Antimicrobial activity of turmeric extract and its potential use in food industry. J Food Sci Technol 2015;52:2272–9.
[15] Yun DG, Lee DG. Antibacterial activity of curcumin via apoptosislike response in Escherichia coli. Appl Microbiol Biotechnol 2016;100:5505–14.
[16] Kinney SR, Carlson L, Ser-Dolansky J, Thompson C, Shah S, Gambrah A, Xing W, Schneider SS, Mathias CB. Curcumin ingestion inhibits mastocytosis and suppresses intestinal anaphylaxis in a murine model of food allergy. PLoS One 2015;10:e0132467.
《中国临床营养网》编辑部
特别声明:以上内容(如有图片或视频亦包括在内)为自媒体平台“网易号”用户上传并发布,本平台仅提供信息存储服务。
Notice: The content above (including the pictures and videos if any) is uploaded and posted by a user of NetEase Hao, which is a social media platform and only provides information storage services.