全生姜提取物能诱导前列腺癌细胞死亡-美国GEORGE STATE UNIVERSITY

值得注意的是，每日口服100 mg/kg体重的生姜提取物小鼠，在裸鼠体内的PC-3异种移植物的生长和进展都受到了大约56%的抑制，如肿瘤体积的测量。通过免疫印迹法和免疫组化法测定，用生姜提取物处理的小鼠肿瘤组织显示其增殖指数下降，凋亡广泛。最重要的是，生姜提取物并没有在正常的、快速分裂的组织如肠道和骨髓中产生任何可检测的毒性。据我们所知，这是第一个在体外和体内抗肿瘤活性的报告，用于治疗前列腺癌。（原创 转载请联系作者）欢迎关注我的大鱼号：健康创客蓝山 -畅游知识海洋 升华健康智慧参考文献：Benefits of whole ginger extract in prostate cancerPrasanthi Karna,1 Sharmeen Chagani,1 Sushma R. Gundala,1 Padmashree C. G. Rida,1 Ghazia Asif,1 Vibhuti Sharma,1 Meenakshi V. Gupta,2 and Ritu Aneja1,*Source: Department of Biology, Georgia State University, Atlanta, GA 30303, USA2West Georgia Hospitals, LaGrange, GA 30240, USAIt is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.Keywords: Ginger extract, Prostate cancer, Apoptosis, Cell cycle, Chemopreventionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426621/