关注：复旦大学张颖/张文宏的文章被撤回

2014年7月，复旦大学张颖/张文宏共同通讯在DNA AND CELL BIOLOGY在线发表了题为“HBx elevates oncoprotein AEG-1 expression to promote cell migration by downregulating miR-375 and miR-136 in malignant hepatocytes”的研究论文(10.1089/dna.2014.2376)，文章第一作者赵静（ jing zhao音译）。该研究发现，miR-375 和 miR-136具有治疗有乙肝病毒 X 蛋白 (HBx)相关的肝细胞癌 (HCC) 的潜力。

近日，该文章被质疑图片重复使用。

图源pubpeer

一位读者联系了文章的第一作者赵静博士，告知作者图 2F文章的“Ctr”和“HBx+si-1”可能来自同一个样本。作者检查了两张图片后表示：图片确实有问题，是一个粗心的错误。

2021年9月，论文作者对该文章进行了修正，对图片进行了替换，并将更新后的手稿提交给了DNA AND CELL BIOLOGY杂志。

2021年10月，DNA and Cell Biology 正式对该论文作出撤稿处理，并称原因在于更新后的实验结果并非是在原始实验产生的。

撤稿全文如下：

RETRACTION NOTICE

Retraction of: HBx Elevates Oncoprotein AEG-1 Expression to Promote Cell Migration by Downregulating miR-375 and miR-136 in Malignant Hepatocytes (10.1089/dna.2014.2376)

DNA and Cell Biology officially retracts the paper entitled, ‘‘HBx Elevates Oncoprotein AEG-1 Expression to Promote Cell Migration by Downregulating miR-375 and miR-136 in Malignant Hepatocytes,’’ by Jing Zhao, Wenjie Wang, Yuxian Huang, Jing Wu, Mingquan Chen, Peng Cui, Wenhong Zhang, and Ying Zhang (DNA and Cell Biology; doi: 10.1089/ dna.2014.2376).

After the journal has published a post-publication correction to the article,1 additional considerations were made after revisiting the recently released guidelines by STM: Advancing Trusted Research.2 These recommendations indicate that replicative experiments should not be permitted if they were not generated at the time of the original experimentation.3[section A2(4)] The Editor and Publisher of DNA and Cell Biology are committed to preserving the scientific literature and the community it serves, and abides by all standard guidelines for, and proper protocols of, scientific publishing.

References

1. [No author(s) listed]. Correction to: HBx elevates oncoprotein AEG-1 expression to promote cell migration by downregulating miR-375 and miR-136 in malignant hepatocytes by Zhao et al. Epub 2021 Sep 27. doi: 10.1089/dna.2014.2376.correx

2. Working Group on Image Alterations and Duplications. STM STEC Working Group on Image Alterations and Duplications. https://www.stm-assoc.org/standards-technology/working-group-on-image-alterations-and-duplications/ Last accessed Sept. 29, 2021.

3. STM Working Group on Image Alteration and Duplication Detection. STM Recommendations for handling image integrity issues. https://osf.io/kgyc6/ Last accessed Sept. 29, 2021.

参考消息：

https://www.liebertpub.com/doi/pdf/10.1089/dna.2014.2376.retract

https://www.liebertpub.com/doi/pdf/10.1089/dna.2014.2376.correx

https://pubpeer.com/publications/6C6ED93F0EDAC6471466D462CD1097

来源：Pubpeer；DNA AND CELL BIOLOGY官网；Retraction；科研大匠

高教志 ID：cncollege

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