两者有共同意思“代替”，但两者的用法有很大不同。
一、词性不同
1、instead 为副词，相当于 rather than 或 as an alternative，只能修饰动词或是句子，它的位置比较灵活，可以放在句首或句尾，在口语中，更经常放在句尾，例如：
句首：
Instead, let all of that teach you what it can.
相反，让所有这些教会你它能做什么。
Holidays in Italy are too expensive. Instead, we're going to Greece.
在意大利度假太贵了。相反，我们要去希腊。
句尾：
If you can't sign your name, make a cross instead.
如果你不会签名画个十字来代替。
I'm going to drop yoga and do aerobics instead.
我要放弃瑜伽，改做有氧运动。
2、instead of 是介词短语，后面一般接名词、代词、动名词或介词短语作它的宾语，相当于 as an alternative，可以放在句首或句尾，例如：
instead of + 名词:
I'll go instead of Jack.
我代替杰克去。
I'll have tea instead of coffee.
我要茶而不是咖啡。
Instead of tea or coffee, drink water to quench your thirst.
渴了喝水，别喝茶或咖啡。
We did the logo in lower-case letters instead of capitals.
我们的徽标用了小写字母，没用大写。
instead of + 代词
You can go instead of me, if you want.
如果你愿意，你可以代替我去。
It felt like I'd had two babies instead of one.
我感觉像是有两个孩子而不是一个。
It looks like an innocent bystander was killed instead of you.
看起来是一个无辜的旁观者当了你的替死鬼。
instead of + V-ing:
He went alone instead of waiting for me.
他一个人去而不是等我。
Instead of complaining, why don't we try to change things?
与其抱怨，不如试着改变一下？
We are learning how to confront death instead of avoiding its reality.
我们在学习如何直面死亡，而非回避死亡这一现实。
instead of + 介词短语:
We went by train instead of by car.
我们坐火车而不是汽车去的。
In future the President will be chosen by the people instead of by the National Assembly.
今后总统将由人民选举产生，而非国民议会选出。
二、词义的侧重点不同
1、instead 句中的动作是要去做的，例如：
I'm too tired to play football today. I'm going to stay at home instead.
我今天太累了，不能踢足球。我要呆在家里。
解析：呆在家里是要去做的动作。
Holidays in Italy are too expensive so we're going to Greece instead.
在意大利度假太贵了，所以我们改去希腊。
解析：去希腊是要去做的动作。
2、instead of 句中的动作或是对象是要被替代的，例如：
Now I can walk to work instead of going by car.
现在我可以步行去上班，而不必开车了。
解析：开车是要被替代的动作。
You can go instead of me, if you want.
如果你愿意，你可以代替我去。
解析：我是要被替代的对象。
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