欧盟评估非转基因拟棘孢曲霉菌株CBS 148915生产的阿拉伯糖内切-1,5-α-L-阿拉伯聚糖酶的安全性

核心提示：2025年10月21日，欧盟食品安全局就一种阿拉伯糖内切-1,5-α-L-阿拉伯聚糖酶（arabinan endo-1,5-α-L-arabinanase）的安全性评价发布意见。……（世界食品网-www.shijieshipin.com）

　　 2025年10月21日，欧盟食品安全局就一种阿拉伯糖内切-1,5-α-L-阿拉伯聚糖酶（arabinan endo-1,5-α-L-arabinanase）的安全性评价发布意见。
　　据了解，这种食品酶是由非转基因拟棘孢曲霉菌株CBS 148915生产的，旨在用于12种食品生产过程。

　　经过评估，专家小组认为，在预期的使用条件下，不能排除饮食暴露引起过敏反应的风险，但这种情况发生的可能性很低。根据所提供的数据，评估小组得出结论，在预期使用条件下（不包括果汁生产中的使用），这种食品酶不会引起安全问题。部分原文报道如下：

　　The food enzyme arabinan endo-1,5-α-L-arabinanase (5-α-L-arabinan 5-α-L-arabinanohydrolase; EC 3.2.1.99) is produced with the non-genetically modified Aspergillus aculeatinus strain CBS 148915 by Solyve. The food enzyme was considered free from viable cells of the production organism. The applicant proposed the use of the food enzyme in 12 food manufacturing processes. Since the use of the enzyme in one proposed use is not allowed in the European Union and residual amounts of food enzyme–total organic solids (TOS) are removed in four processes, dietary exposure was calculated for the remaining seven food manufacturing processes. It was estimated to be up to 1.499 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 301 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 201. A search for the homology of the amino acid sequence of the arabinan endo-1,5-α-L-arabinanase to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use in 11 food manufacturing processes (excluding the use in the production of juices).