广东
皮肤组织损伤容易引发细菌感染，感染导致持续炎症，阻碍伤口愈合进程，甚至发展成难以愈合的慢性伤口。为了防止继发性皮肤损伤，人们开发了各种新型创面敷料，如海绵、薄膜、水凝胶等。与其他伤口敷料相比，水凝胶具有独特的三维网状结构，优异的渗出液吸收能力，成为了伤口敷料的极佳选择。在先前的研究中报道了几种先进的可视化感染检测和抗菌贴片系统，通过将不同的细菌诱导变色材料和光热/光动力材料整合到各种水凝胶基质中，可以制备出具有感染可视化检测和光疗灭菌功能的智能贴片系统。然而，这些项目面临着一些挑战。例如，部分水凝胶基质不是由天然大分子组成，这影响了其生物相容性;同时，某些材料中含有的重金属元素可能会带来潜在的安全风险。近日，研究人员以壳聚糖和琼脂糖为水凝胶基质，制备了一种具有比色检测和光动力抗菌功能的三明治型水凝胶贴片（CABP）。相关研究结果发表于International Journal of Biological Macromolecules。
制备的水凝胶贴片（CABP）具有更好的生物相容性，当发生金黄色葡萄球菌（S. aureus）感染时，环境pH值降低，触发CABP由原来的蓝色变为黄色，实现直观的视觉转变。此外，在660 nm光照下，CABP贴片对金黄色葡萄球菌的抑制率高达99.99971%，显示出良好的光动力治疗/化疗协同效应。综上，该研究展示了CABP贴片为细菌感染的可视化检测和抗菌治疗提供了新的思路。
Chitosan/agarose hydrogel dressing: pH response real-time monitoring and chemo-/photodynamic therapy synergistic treatment of infected wounds.
The early diagnosis and real-time monitoring of bacterial infections are of great significance for the establishment of integrated diagnosis and treatment systems. In this study, a pH-responsive smart hydrogel patch system, named CABP, was developed to monitor and treat wound infections. CABP has a sandwich structure, with nonwoven fabric/chitosan (NF/CS) as the intermediate skeleton layer, Agarose/chitosan/Bromothymol Blue (AG/CS/BTB) hydrogel as the detection layer, and Agarose/chitosan/phthalocyanine (AG/CS/Pc) hydrogel as the treatment layer. When Staphylococcus aureus (
S. aureus) infection occurs, the pH of the environment decreases, which triggers the CABP to change from its original blue color to yellow, achieving an intuitive visual transformation. Moreover, the hydrogel patch showed a significant inhibition rate of up to 99.99971 % against
S. aureusunder 660 nm light radiation, showing a good photodynamic therapy (PDT)chemotherapy (CT) synergistic effect. In addition, CABP showed excellent antibacterial and wound healing effects on
S. aureusinfection in a full-layer skin defect experiment. In short, the patch system is simple to prepare and easy to use, and can provide important research value for the integrated diagnosis and treatment system in biomedical applications.
网页链接：https://doi.org/10.1016/j.ijbiomac.2024.134513
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