聚焦生命科学！《Nature》主刊对昌平“生命谷”进行整版报道！

2月29日，《Nature》主刊刊登题为《The upward trajectory of China’s ‘Silicon Valley’ for the life sciences》（中国生命科学“硅谷”蓬勃发展）文章，对昌平“生命谷”进行整版报道，重点介绍了中关村生命科学园、生命科学创新走廊、生命科学国际论坛活动及昌平医药健康产业发展情况。

In the post-pandemic world, the life sciences are taking centre stage. From Boston’s Kendall Square to Singapore’s Biopolis, innovation districts that focus on the life sciences have the potential to fuel national economies, transform health and improve quality of life.One such district is the Changping’s Life Valley, a sprawling zone of research institutions and pharmaceutical and health enterprises clustered across more than seven square kilometres in the Changping district, a suburb in Beijing’s northwest with stunning mountain views.Much of Life Valley is the Zhongguancun (ZGC) Life Science Park.The park, which is the beneficiary of 20 years of government support, is expected to grow significantly in coming years. Three new zones are being developed: the Frontier Technology zone, the Medical Device zone, and the Beauty and Health zone.To speed the development of the pharmaceutical and health industry across Life Valley, the Changping District local government is also introducing new policies.These include the ‘industry multiplication’ action plan — which provides additional investment, support for talent development and infrastructure — and blueprints for the construction of a life sciences innovation corridor, Changping District Mayor Zhi Xianwei told the 2023 Beijing-Changping International Forum on Life Science, in November 2023.“It is imperative to develop the infrastructure and provide policy support for Life Valley,” Qiang Liu, the deputy governor of Changping district, later told attendees at the opening of the ‘Drug Discovery and Development Forum of the ZGC Life Science Park’.The event, organized by Beijing Changping People’s Government, with the support of Nature Research Custom Media, was part of the 2023 Beijing-Changping International Forum on Life Science.

Fertile endeavours

Founded in 2000, the life science park is home to hundreds of pharmaceutical, biotech, medical and academic enterprises (see box, below). The proximity of so many R&D related enterprises, together with high-profile conferences and events, is helping catalyse all steps of the innovation life cycle, from basic research to development, prototyping, pilot production and distribution, says Zhi.

Close to 80 billion RMB (US$11.2 billion) revenue was reported in 2022 from Changping’s pharmaceutical and health industry.

Notable products to come out of the Life Valley include a US Food and Drug Administration-approved anti-cancer drug developed by BeiGene, a Chinese company that has expanded globally.

Beijing GoBroad Hospital, in the ZGC Life Science Park, is among China’s first international research hospitals.

Meeting of minds

“It was fascinating to visit China and see the amount of investment going into research, as well as to see the types of research that are of interest,” says neuroscientist Antonia Hamilton, of University College London in the United Kingdom. Hamilton was a key speaker at ‘The Great Brain Exploration: from Cognition to Brain-Inspired Technology’, held in the life science park on 7-8 December 2023, a satellite event of the Beijing-Changping International Forum on Life Science.

Conferences such as these are key to stimulating research and innovation in Changping’s Life Valley, says Liu. Symposiums and forums on frontier topics in the life sciences, featuring prominent national and international researchers, take place here year-round.

“Having the opportunity to meet researchers in China and find out more about their work is valuable,” says Hamilton, who shared her research on neurocognition and how humans use imitation to send nonverbal signals, a process that can be disrupted in people with autism.

“Communication between China and the rest of the world is very important,” agrees cell biologist, Junying Yuan, of Shanghai Institute of Organic Chemistry, part of the Chinese Academy of Sciences, who was a speaker at the ‘Drug Discovery and Development Forum of the ZGC Life Science Park’.

The park lies within the Changping’s ‘Life Valley’, which is famous for its mountain views and proximity to the Juyong pass of the Great Wall of China.

Fresh pastures

At the event, Yuan shared the results of her research on RIPK1 — a kinase enzyme and a signalling molecule involved in cellular pathways related to cell survival and death.RIPK1 is an important pharmacological target for drugs designed to treat human neurodegenerative diseases, she told the meeting.Looking to the future, “the park will further expand to the north,” says Zhi. “There will be more research and research translation in the fields of cell and gene therapy, artificial intelligence, medical device research and development, synthetic biology, and innovative drugs.”Within five years, the park will be expanded to three major zones, he explains: The Frontier Technology zone, which will include R&D in cell and gene therapy, digital medicine, and synthetic biology. The Medical Device zone, which includes brain-computer interfaces, digital medicine, implant technology and high-end diagnostics. Finally, the Beauty and Health zone, provisionally called the ‘Xiaotangshan Beauty Intelligence Park’, will host research institutions and enterprises working on scientifically based cosmetics and nutritional services.The Life Valley International Precision Medicine Industrial Park, the Life Valley Bio-engineering Innovation Centre, and the SINOVAC High Precision Achievement Transformation Base are already being built.

“More life science innovation will be happening in Changping,” says Zhi. “With strong support, there will one day be a pharmaceutical and health hub worth 100 billion.”