复旦大学生命科学学院王永明教授博士后招聘启事

复旦大学生命科学学院王永明教授博士后招聘启事

王永明，博士生导师。2010年获得柏林自由大学博士学位；2010-2013年在斯坦福大学医学院从事博士后研究；2013年至今在复旦大学生命科学学院工作。王永明课题组隶属复旦大学遗传工程国家重点实验室，主要开发新型CRISPR工具，并进行心肌病基因治疗研究。先后获得国家青年人才计划和国家领军人才计划。

应聘条件：

1、有小鼠操作经验、基因编辑、多能干细胞培养或者心肌病研究背景的优先。
2、发表过二区以上论文一篇。

工资待遇： >40万/年

实验室链接：

https://life.fudan.edu.cn/e7/3d/c28175a386877/page.htm

主要研究方向：

1、开发新型CRISPR工具。

2、运用CRISPR技术进行基因治疗研究。

近期代表性成果：

1. Tao Qi, Yao Wang, Yuan Yang, Siqi Gao, Jingtong Liu, Qiang Huang, Yuwen Tian, Junnan Tang*, Wei Zheng*,Yongming Wang*. Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM.Nature Chemical Biology. 2023 Dec 6.

2. Man Qi#, Shuhong Ma#, Jingtong Liu#, Xujie Liu, Jingjing Wei, Wen-Jing Lu, Siyao Zhang, Yun Chang, Yongshuai Zhang, Kejia Zhong, Yuting Yan, Min Zhu, Yabing Song, Yundai Chen, Guoliang Hao, Jianbing Wang, Li Wang, Andrew S Lee, Xiangbo Chen*,Yongming Wang*, Feng Lan*. In vivo base editing of Scn5a rescues type 3 long QT syndrome in mice.Circulation. 2023 Nov 15.

3. Chengdong Zhang#, Yuan Yang#, Tao Qi, Yuening Zhang, Linghui Hou, Jingjing Wei, Jingcheng Yang, Leming Shi, Sang-Ging Ong, Hongyan Wang, Hui Wang*, Bo Yu*, Yongming Wang*. Prediction of base editor off-targets by deep learning.Nature communications. 2023 Sep 2;14(1):5358.

4. Yao Wang, Tao Qi,Jingtong Liu, Yuan Yang, Ziwen Wang, Ying Wang, Tianyi Wang, Miaomiao Li,Mingqing Li, Daru Lu, Alex Chia Yu Chang, Li Yang, Song Gao, Yongming Wang*, Feng Lan*. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing.Science Advances. 2023.

5. Gao#,Yao Wang#, Tao Qi#,Jingjing Wei, Ziying Hu, Jingtong Liu, Shuna Sun*, HuihuiLiu*,Yongming Wang*. Genomeediting with natural and engineered CjCas9 orthologs.Molecular Therapy. 2023.

6. ShuaiWang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-GingOng, Shijun Hu*, Renjie Chai*,YongmingWang*. Identification of SaCas9 orthologs containing a conserved serineresidue that determines simple NNGG PAM recognition.PLoS Biology. 2022.

7.Jingjing Wei, LinghuiHou, Jingtong Liu, Ziwen Wang, Siqi Gao, Tao Qi, Song Gao, Shuna Sun*, Yongming Wang*. Closely related type II-CCas9 orthologsrecognize diverse PAMs.Elife. 2022.

8. ShuaiWang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi,Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu,Renjie Chai*,Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM.Advanced Science. 2021.

9. ShuhongMa#,Wenjian Jiang#, Xujie Liu#,Wen-Jing Lu, Tao Qi, Jingjing Wei, FujianWu, Yun Chang, Siyao Zhang, Yabing Song, Rui Bai, Jianbing Wang, Andrew S. Lee, Hongjia Zhang*, Yongming Wang*, Feng Lan*. Efficient Correction of a HypertrophicCardiomyopathy Mutation by ABEmax-NG.Circulation Research. 2021.

10. Ziying Hu #,Chengdong Zhang#, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, LinghuiHou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, HongyanWang*, Jixi Li*,Yongming Wang*. Discoveryand engineering of small SlugCas9 with broad targeting range and highspecificity and activity.Nucleic Acids Research. 2021.

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