2023 ASCO前瞻 | 肺癌领域重磅研究一览（含中国研究35项）

一年一度的全球肿瘤界盛会-美国临床肿瘤学会（ASCO）年会将于当地时间6月2日-6月6日召开。ASCO年会是世界上规模最大、学术水平最高、最具权威的临床肿瘤学会议。医脉通精选了肺癌领域相关重磅研究，其中包含中国学者将公布的35项研究。

全体大会专场（Plenary Session）

摘要号: LBA3

Overall survival analysis from the ADAURA trial of adjuvant osimertinib in patients with resected EGFR‑mutated (EGFRm) stage IB–IIIA non-small cell lung cancer (NSCLC).

报告人: Roy S. Herbst

口头报告专场（Oral Abstract Session）

局部非小细胞/小细胞/其他胸部肿瘤

摘要号: 8500

Surgical outcomes of patients with resectable non-small-cell lung cancer receiving neoadjuvant immunotherapy with nivolumab plus relatlimab or nivolumab: Findings from the prospective, randomized, multicentric phase II study NEOpredict-Lung.

报告人: Clemens Aigne

摘要号: 8501

Perioperative toripalimab + platinum-doublet chemotherapy vs chemotherapy in resectable stage II/III non-small cell lung cancer (NSCLC): Interim event-free survival (EFS) analysis of the phase III NEOTORCH study.

报告人：陆舜，上海交通大学医学院附属胸科医院

摘要号: 8502

First-in-human dose-escalation trial of the delta-like ligand 3 (DLL3)/CD3 bispecific T-cell engager BI 764532 in patients (pts) with DLL3-positive (DLL3+) small-cell lung cancer (SCLC) and neuroendocrine carcinoma (NEC).

报告人: Martin Wermke

摘要号: 8503

Exploratory biomarker analysis of the phase 3 KEYNOTE-604 study of pembrolizumab plus etoposide for extensive-stage SCLC.

报告人: Charles M. Rudin

摘要号: 8504

SWOG S1929: Phase II randomized study of maintenance atezolizumab (A) versus atezolizumab + talazoparib (AT) in patients with SLFN11 positive extensive stage small cell lung cancer (ES-SCLC).

报告人: Nagla Fawzy Abdel Karim

口头报告专场（Oral Abstract Session）

转移性非小细胞肺癌

摘要号: LBA9000

Pemetrexed and platinum with or without pembrolizumab for tyrosine kinase inhibitor (TKI)-resistant, EGFR-mutant, metastatic nonsquamous NSCLC: Phase 3 KEYNOTE-789 study.

报告人: James Chih-Hsin Yan

摘要号: 9001

Randomized phase 3 study of first-line AZD3759 (zorifertinib) versus gefitinib or erlotinib in EGFR-mutant (EGFRm+) non–small-cell lung cancer (NSCLC) with central nervous system (CNS) metastasis.

报告人：吴一龙，广东省人民医院&广东省肺癌研究所

摘要号: 9002

Sunvozertinib for the treatment of NSCLC with EGFR Exon20 insertion mutations: The first pivotal study results.

报告人：王孟昭，北京协和医院

摘要号: 9003

Final overall survival and biomarker analyses of CHOICE-01: A double-blind randomized phase 3 study of toripalimab versus placebo in combination chemotherapy for advanced NSCLC without EGFR/ALK mutations.

报告人: 邬麟，湖南省肿瘤医院

摘要号: 9004

TROPION-Lung02: Datopotamab deruxtecan (Dato-DXd) plus pembrolizumab (pembro) with or without platinum chemotherapy (Pt-CT) in advanced non-small cell lung cancer (aNSCLC).

报告人: Yasushi Goto

摘要号: LBA9005

Tumor Treating Field (TTFields) therapy with standard of care (SOC) in metastatic non-small cell lung cancer (mNSCLC) following platinum failure: Randomized, phase 3 LUNAR study.

报告人: Ticiana Leal

摘要号: 9006

The primary endpoint analysis of SCARLET study: A single-arm, phase II study of sotorasib plus carboplatin-pemetrexed in patients with advanced non-squamous, non-small cell lung cancer with KRAS G12C mutation (WJOG14821L).

报告人: Hiroaki Akamatsu

摘要号: 9007

KontRASt-01 update: Safety and efficacy of JDQ443 in KRAS G12C-mutated solid tumors including non-small cell lung cancer (NSCLC).

报告人: Philippe Alexandre Cassier

摘要号: 9008

Biomarker subgroup analyses of CodeBreaK 200, a phase 3 trial of sotorasib versus (vs) docetaxel in patients (pts) with pretreated KRAS G12C-mutated advanced non-small cell lung cancer (NSCLC).

报告人: Ferdinandos Skoulidis

临床科学论坛（Clinical Science Symposium）

EGFR突变肺癌新进展

摘要号: 8508

Phase II trial of neoadjuvant osimertinib for surgically resectable EGFR-mutated non-small cell lung cancer.

报告人: Jacqueline V

摘要号: LBA9009

A phase III study comparing EGFR tyrosine kinase inhibitor (EGFR-TKI) monotherapy and EGFR-TKI with inserted cisplatin (CDDP) plus pemetrexed (PEM) as a first-line treatment in patients (pts) with advanced non-squamous non–small-cell lung cancer (NSqNSCLC) harboring EGFR activating mutation (EGFR-NSqNSCLC): JCOG1404/WJOG8214L, AGAIN study.

报告人: Shintaro Kanda

摘要号: 9013

Predictive biomarkers for treatment with amivantamab plus lazertinib among EGFR-mutated NSCLC in the post-osimertinib setting: Analysis of tissue IHC and ctDNA NGS.

报告人: Benjamin Besse

临床科学论坛（Clinical Science Symposium）

实体瘤新辅助免疫治疗

摘要号: LBA100

KEYNOTE-671: Randomized, double-blind, phase 3 study of pembrolizumab or placebo plus platinum-based chemotherapy followed by resection and pembrolizumab or placebo for early stage NSCLC.

报告人: Heather A

快速摘要专场（Rapid Abstract Session）

肺癌

摘要号: 8509

Pembrolizumab and ramucirumab neoadjuvant therapy for PD-L1-positive stage IB-IIIA lung cancer (EAST ENERGY).

报告人: Keiju Aokage

摘要号: 9011

BLU-945 monotherapy and in combination with osimertinib (OSI) in previously treated patients with advanced EGFR-mutant (EGFRm) NSCLC in the phase 1/2 SYMPHONY study.

报告人: Yasir Y Elamin

摘要号: 9012

First-line immune checkpoint inhibitors alone or in combination with chemotherapy in real-life elderly patients with advanced non-small cell lung cancer (NEJ057).

报告人: Mao Uematsu

壁报讨论（Poster Discussion Session）

局部非小细胞/小细胞/其他胸部肿瘤

摘要号: 8512

海报号: 139

Final survival data from a randomized phase II trial comparing high-dose with standard-dose twice-daily (BID) thoracic radiotherapy (TRT) in limited stage small-cell lung cancer (LS SCLC).

报告人: Bjorn H. Henning Gronberg

摘要号: 8518

海报号: 145

Phase II study of durvalumab plus olaparib as maintenance therapy in extensive-stage small-cell lung cancer (TRIDENT): Preliminary efficacy and safety results.

报告人：黄岩，中山大学肿瘤防治中心

摘要号: 8519

海报号: 146

Associations between patient-reported nutritional status, survival, and toxicity among patients with limited stage small-cell lung cancer (LS SCLC) in a randomized trial of high-dose, twice-daily (BID) thoracic radiotherapy (TRT).

报告人: Evgenia Taranova

摘要号: 8520

海报号: 147

Pembrolizumab vs placebo for early-stage non‒small-cell lung cancer after resection and adjuvant therapy: Subgroup analysis of patients who received adjuvant chemotherapy in the phase 3 PEARLS/KEYNOTE-091 study.

报告人: Kersti Oselin

摘要号: 8521

海报号: 148

Clinical outcomes with neoadjuvant nivolumab (N) + chemotherapy (C) vs C by definitive surgery in patients (pts) with resectable NSCLC: 3-y results from the phase 3 CheckMate 816 trial.

报告人: Jonathan Spicer

摘要号: 8522

海报号: 149

IMpower010: Exploratory analysis of disease-free survival by KRAS status in patients with stage II-IIIA NSCLC treated with adjuvant atezolizumab vs best supportive care.

报告人: Martin Reck

摘要号: 8523

海报号: 150

Response to neoadjuvant immune checkpoint inhibitor (ICI)-based therapy in oncogene-driven resectable non-small cell lung cancer (NSCLC).

报告人: Samuel Rosner

壁报讨论（Poster Discussion Session）

转移性非小细胞肺癌

摘要号:9025

海报号: 1

SI-B001 plus chemotherapy in patients with locally advanced or metastatic EGFR/ALK wild-type non-small cell lung cancer: A phase II, multicenter, open-label study.

报告人：赵媛媛，中山大学肿瘤防治中心

摘要号: 9014

海报号: 2

Safety and preliminary efficacy of YK-029A, a novel EGFR TKI, in patients with advanced NSCLC harboring ex20ins, T790M or rare mutations.

报告人: 段建春，中国医学科学院肿瘤医院

摘要号: 9015

海报号: 3

FAK inhibition with novel FAK/ALK inhibitor APG-2449 could overcome resistance in NSCLC patients who are resistant to second-generation ALK inhibitors.

报告人: 马宇翔，中山大学肿瘤防治中心

壁报专场（Poster Session）

局部非小细胞/小细胞/其他胸部肿瘤

摘要号: 8525

海报号: 152

Safety and efficacy of QL1706 plus carboplatin/etoposide (EC) as first-line (1L) treatment for extensive-stage small-cell lung cancer (ES-SCLC): The results from a phase II single-arm study.

报告人: 范云，浙江省肿瘤医院

摘要号: 8528

海报号: 155

Dynamic ctDNA to inform the precise management of resected NSCLC: LUNGCA-2 study.

报告人: 夏粱，四川大学华西医院

摘要号: 8540

海报号: 167

Stereotactic body radiation therapy with sequential immunochemotherapy as neoadjuvant therapy in resectable non-small cell lung cancer (SACTION-01 study).

报告人: 赵泽锐，中山大学肿瘤防治中心

摘要号: 8548

海报号: 175

Sequential intravenous chemotherapy with drug-eluting bead bronchial arterial chemoembolization for the treatment of stages III and IV lung squamous cell carcinoma: A retrospective controlled clinical study.

报告人: Jianfei Tu，温州医科大学第五附属医院

摘要号: 8549

海报号: 176

Prospective dynamic sampling and molecular residual disease monitoring to predict clinical outcomes for patients with unresectable, locally advanced non-small cell lung cancer undergoing radical radiotherapy.

报告人: 张嘉涛，广东省人民医院&广东省肺癌研究所

摘要号: 8555

海报号: 182

Assessing the efficacy and safety of DEB-BACE combined with intravenous chemotherapy for the treatment of intermediate to advanced lung adenocarcinoma after progression of targeted drug resistance.

报告人: Lingqiang Lai，温州医科大学第五附属医院

摘要号: 8564

海报号: 191

Phase II trial of safety and efficacy of tislelizumab plus chemotherapy in stage II-IV non small cell lung cancer (LungMark).

报告人: 林耀彬，中山大学肿瘤防治中心

摘要号: 8579

海报号: 206

Phase I/II combination study of tifcemalimab with toripalimab in patients with refractory extensive stage small cell lung cancer (ES-SCLC).

报告人: 程颖, 吉林省肿瘤医院

摘要号: 8580

海报号: 207

Updated safety and efficacy results of SHR-1316 combined with chemotherapy and sequential chest radiotherapy as first-line therapy for extensive-stage small cell lung cancer (ES-SCLC) from a phase II trial.

报告人：陈大卫，山东省肿瘤医院

摘要号: 8585

海报号: 212

Phase Ib/IIa study assessing the safety and efficacy of AL8326 monotherapy in patients with ≥3rd line small cell lung cancer (SCLC) treatment.

报告人：张晓春，青岛大学附属医院

摘要号: 8590

海报号: 217

A multicenter phase I/II trial of induction chemotherapy followed by camrelizumab, apatinib, plus chemotherapy as first-line treatment for extensive-stage small-cell lung cancer.

报告人: 刘明，广州医科大学附属第一医院

壁报专场（Poster Session）

转移性非小细胞肺癌

摘要号: 9036

海报号: 24

Efficacy and safety of polymeric micelle paclitaxel (pm-Pac) plus tislelizumab and carboplatin for first-line treatment of patients with advanced squamous non-small-cell lung cancer.

报告人: 史美祺，江苏省肿瘤医院

摘要号: 9041

海报号: 29

Pre-treatment plasma-informed circulating tumor DNA detection as an early identification of therapeutic benefit for patients with untreated advanced lung squamous cell carcinoma.

报告人: 蒋涛，同济大学医学院附属上海市肺科医院

摘要号: 9062

海报号: 50

Mechanisms of resistance to tyrosine kinase inhibitor treatments in patients with ROS1 fusion-positive non-small cell lung cancer.

报告人: 王佳蕾，复旦大学附属肿瘤医院

摘要号: 9066

海报号: 54

Efficacy and safety of PD-1/PD-L1 inhibitor plus platinum-based chemotherapy vs. platinum-based chemotherapy alone in patients with previously untreated advanced large-cell neuroendocrine cancer of the lung.

报告人: Fengchun Mu，山东省肿瘤医院

摘要号: 9073

海报号: 61

Efficacy and safety of sunvozertinib in treatment naïve NSCLC patients with EGFR exon20 insertion mutations.

报告人: Yan Xu，中国医学科学院北京协和医院

摘要号:9081

海报号: 69

Patient-reported outcomes of furmonertinib versus gefitinib in patients with locally advanced or metastatic, EGFR mutation-positive non-small cell lung cancer (FURLONG): A multicenter, double-blind, randomized phase 3 study.

报告人:石远凯，中国医学科学院肿瘤医院

摘要号: 9080

海报号: 68

Tislelizumab plus chemotherapy in patients with advanced brain metastases of non-squamous non-small cell lung cancer: A multicenter, prospective, open-label phase 2 study.

报告人: 黄岩，中山大学肿瘤防治中心

摘要号: 9087

海报号: 75

Phase II results of ivonescimab (AK112/ SMT112), a novel PD-1/VEGF bispecific, in combination with chemotherapy for first line treatment of advanced or metastatic non-small cell lung cancer (NSCLC) without actionable genomic alterations (AGA) in EGFR/ALK.

报告人: 张力，中山大学肿瘤防治中心

摘要号: 9096

海报号: 84

Long-term outcome for patients with advanced non‒small-cell lung cancer treated by autologous cytokine-induced killer (CIK) cell immunotherapy in combination with sintilimab plus chemotherapy: NSCLC-CCICC-002.

报告人: Liang Liu，天津医科大学肿瘤医院

摘要号: 9105

海报号: 93

Safety and efficacy of inetetamab in combination with pyrotinib in HER2 mutant patients with non-small cell lung cancer (NSCLC): An open-label, phase Ib trial.

报告人：方文峰，中山大学肿瘤防治中心

摘要号: 9106

海报号: 94

Dacomitinib for patients with non-small cell lung cancer harboring uncommon epidermal growth factor receptor mutations: Do mutation patterns matter?

报告人: Hong-Shuai Li，中国医学科学院肿瘤医院

摘要号: 9110

海报号: 98

Efficacy and safety of SY-3505, a third-generation ALK TKI, in ALK-positive advanced non-small cell lung cancer: Results from a phase I/II, multi-center study.

报告人:石远凯，中国医学科学院肿瘤医院

摘要号: 9111

海报号: 99

A first-in-human phase I, dose-escalation and dose-expansion study of SY-5007, a highly potent and selective RET inhibitor, in Chinese patients with advanced RET positive solid tumors.

报告人: 周彩存, 同济大学医学院附属上海市肺科医院

摘要号: 9113

海报号: 101

First-in-human, multicenter phase Ⅰ study of TGRX-326 in patients with advanced ALK-positive non-small cell lung cancer.

报告人：赵洪云，中山大学肿瘤防治中心

摘要号: 9114

海报号: 102

SKB264 (TROP2-ADC) for the treatment of patients with advanced NSCLC: Efficacy and safety data from a phase 2 study.

报告人: 方文峰，中山大学肿瘤防治中心

摘要号: 9131

海报号: 119

A phase 2a study evaluating the efficacy and safety of sutetinib in patients with advanced non–small-cell lung cancer (NSCLC) harboring uncommon EGFR mutations.

报告人: 吴凤英，同济大学医学院附属上海市肺科医院

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编辑：Yuna

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