中稿作品解读
Organic Long-Persistent Luminescence from a Single-Component Aggregate
https://doi.org/10.1021/jacs.1c11480
长余辉发光LPL (Long-persistent luminescence)是一种停止激发光后仍可以进行持续性发光的现象，针对LPL长余辉发光的研究一直受到广泛关注，这是由于对于发展下一代功能性材料非常重要。但是，目前大多数LPL材料都是含有多种组分的无机材料体系，需要复杂的合成过程，而且需要大量稀土元素。
目前由于无机材料体系的缺陷，不含金属的有机长余辉材料受到更多关注。现有的材料中能够产生OLPL最好的方法是通过二元供体-受体激发态复合物得到电荷分离态。但是相关报道中指出，二元供体-受体体系的比例能够影响OLPL性能，因此导致重现性难以实现，同时比较难实现大量合成和应用。因此发展结构更加简单的OLPL体系可能克服这种局限。
有鉴于此，香港科技大学唐本忠等报道设计合成了单一组分的OLPL体系，能够在温和条件中产生12 min的余辉。
本文给出了一种简单的设计新型OLPL材料的方法，为发展新型单一组分OLPL材料提供经验和机会。
中稿作品精选
1丨Vol.3 No.3 March, 2022
标题：
Atomic Lego Catalysts Synthesized by Atomic Layer Deposition
摘要：
Helped by selective deposition, atomic layer deposition, due to its unique character of alternative self-limiting molecular surface reactions, enables catalytic nanostructures to be built on high-surface-area powder substrates atom-by-atom from the bottom up, analogous to toy building blocks, thus providing a powerful approach for catalyst precise synthesis.
论文链接：
https://doi.org/10.1021/accountsmr.1c00250
2丨Vol.14 No.12 March 30, 2022
标题：
Ultrasensitive Analysis of Exosomes Using a 3D Self-Assembled Nanostructured SiO2 Microfluidic Chip
摘要：
Conventional microfluidics with a solid mixer for exosome detection is constrained by the low binding efficiency of the solid–liquid boundary effects and reduced sensitivity of individual markers. Here, we report a 3D-SiO2 porous chip that combines nanoscale porous characteristics and multiple exosome specific markers to greatly improve the sensitivity for biosensing. The lower limit of detection was 220 particles/μL exosomes in PBS. We applied the 3D-SiO2 porous chip for prostate cancer (PCa) staging in mice and early detection of clinical PCa patients. The developed method could significantly differentiate the different stages of PCa in mice and improve the early detection rate in clinical patients. Expression of multiple specific markers in clinical serum samples identified disease fingerprints, alongside histological results, which supports the potential application of exosomes as a noninvasive surrogate biopsy for PCa.
论文链接：
https://doi.org/10.1021/acsami.1c22569
3丨Vol.8 No.3 March, 2022
标题：
Interfacial Superassembly of Mesoporous Titania Nanopillar-Arrays/Alumina Oxide Heterochannels for Light- and pH-Responsive Smart Ion Transport
摘要：
Stimuli-responsive nanochannels have attracted extensive attention in various fields owing to their precise regulation ability of ionic transportation. However, the poor controllability and functionality as well as responding to only one type of external stimulus still impede the development of the smart nanochannels. Here, we demonstrate a novel heterogeneous membrane composed of ordered mesoporous titania nanopillar-arrays/anodic aluminum oxide (MTI/AAO) using an interfacial superassembly strategy, which can achieve intelligent light and pH multimodulation ion transport. The MTI/AAO membranes are generated through the self-assembly of templates, followed by interfacial superassembly of micelles on AAO, and then the nanostructure and phase transformation of titania. The presence of the MTI layer with anatase crystal endows the heterogeneous membrane with an excellent light-responsive current density of 219.2 μA·cm–2, which is much higher than that of a reported traditional light-responsive nanofluidic device. Furthermore, the MTI/AAO heterogeneous membranes with an asymmetric structure exhibit excellent rectification performance. Moreover, pH-regulated surface charge polarity leads to a reversal of current rectification polarity. This light and pH multiresponsive membrane realizes efficient, sensitive, and stable ion regulation, extending the traditional nanochannel from single modulation to smart multimodulation.
论文链接：
https://doi.org/10.1021/acscentsci.1c01402
4丨Vol.56 No.7 April 5, 2022
标题：
Nitrogen-Containing Compounds Enhance Light Absorption of Aromatic-Derived Brown Carbon
摘要：
The formation of secondary brown carbon (BrC) is chemically complex, leading to an unclear relationship between its molecular composition and optical properties. Here, we present an in-depth investigation of molecular-specific optical properties and aging of secondary BrC produced from the photooxidation of ethylbenzene at varied NOx levels for the first time. Due to the pronounced formation of unsaturated products, the mass absorption coefficient (MAC) of ethylbenzene secondary organic aerosols (ESOA) at 365 nm was higher than that of biogenic SOA by a factor of 10. A high NOx level ([ethylbenzene]0/[NOx]0 < 10 ppbC ppb–1) was found to significantly increase the average MAC300–700nm of ESOA by 0.29 m2 g–1. The data from two complementary high-resolution mass spectrometers and quantum chemical calculations suggested that nitrogen-containing compounds were largely responsible for the enhanced light absorption of high-NOx ESOA, and multifunctional nitroaromatic compounds (such as C8H9NO3 and C8H9NO4) were identified as important BrC chromophores. High-NOx ESOA underwent photobleaching upon direct exposure to ultraviolet light. Photolysis did not lead to the significant decomposition of C8H9NO3 and C8H9NO4, indicating that nitroaromatic compounds may serve as relatively stable nitrogen reservoirs and would effectively absorb solar radiation during the daytime.
论文链接：
https://doi.org/10.1021/acs.est.1c08794
5丨Vol.65 No.7 April 14, 2022
标题：
Discovery of a Highly Selective β2-Adrenoceptor Agonist with a 2-Amino-2-phenylethanol Scaffold as an Oral Antiasthmatic Agent
摘要：
Asthma patients in resource-poor countries cannot obtain adequate basic asthma medications because most asthma medications are supplied as inhalants. An alternative approach is to create oral antiasthmatic drugs with high β2/β1-selectivity, which should reduce treatment costs. In this study, we designed a cohort of compounds 1 using 2-(4-amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-butylamino)ethan-1-ol hydrogen chloride (1a) as the lead compound with an aim to expand the library of compounds possessing the 2-amino-2-phenylethanol scaffold. Structure–activity relationship studies on these compounds revealed that compounds created showed remarkable β2 selectivity compared to isoproterenol and gave additional insights on the rational design of β2-adrenoceptor agonists. Moreover, 1a was found as the best candidate compound showing the greatest potential for drug development. Cell-based assays showed that 1a was about 10 times more selective than salbutamol toward the β2-adrenoceptor. Moreover, 1a exhibited good oral bioavailability and low acute oral toxicity. These data reveal 1a as an oral antiasthmatic agent.
论文链接：
https://doi.org/10.1021/acs.jmedchem.1c02006
6丨Vol.61 No.16 April 11, 2022
封面链接：
https://www.jmst.org/EN/article/showOldVolumnList.do
7丨Vol.35 No.4 April, 2022
论文链接：
https://www.amse.org.cn/EN/1006-7191/home.shtml
8丨Vol.45 No.14 April 11, 2022
标题：
Deep and compact dentinal tubule occlusion via biomimetic mineralization and mineral overgrowth
摘要：
Dentinal tubule (DT) occlusion by desensitizing agents has been widely applied to inhibit the transmission of external stimuli that cause dentin hypersensitivity (DH). However, most desensitizing agents merely accomplish porous blocking or the formation of a superficial tubular occlusion layer, resulting in a lack of mechanical and acid resistance and long-term stability. Herein, combining biomimetic mineralization and mineral overgrowth of the dentinal matrix was shown to effectively occlude DTs, resulting in the formation of a compact and deep occluding mineral layer that is strongly bound to the organic matrix on tubule walls. This DT occlusion method could achieve both mechanical resistance and acid resistance, demonstrating the potential of an inexpensive, long-term, and efficient therapy for treating DH.
论文链接：
https://doi.org/10.1039/D1NR05479A
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