浙江
来源：iNature
2026 年 7 月 20 日，邹明辉团队在 Diabetes 杂志上发表的 2 篇研究论文被撤回。
这两篇论文分别发表于 2010 年 3 月 18 日（题为「Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo」）和 2009 年 10 月 26 日（题为「In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I」 ）。
此次撤稿由美国糖尿病协会（ADA）应俄克拉荷马大学健康校区的要求执行，主要原因是纠正因数据不可靠而造成的研究记录问题。
俄克拉荷马大学健康校区对文章中数据真实性的调查得出结论：
图 4C 是伪造的，其内容为重复使用并重新标注了来自先前已撤稿出版物中的免疫印迹（Diabetes 2008;57:3222–3230. DOI: Link to Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes10.2337/db08-0610），且未注明出处。
具体造假内容如下所述：
图 4C 中 β-actin 印迹的第 1–3 条泳道经由 2008 年文章重新使用，其比例已调整，该文章中这些泳道在图 5A 中被报告为 c-Jun 印迹+/-AICAR 处理的第 1–3 条泳道，在图 6C 中则作为 C57BL6 样本的 IP:PGIS/WB:PGIS 印迹的第 1–3 条泳道。
图 4C 中 β-actin 印迹的第 4–6 条泳道在 2008 年文章中已重复使用，其比例已调整。该泳道在图 5A 中作为 p-38 印迹+/-AICAR 处理的第 1–3 条泳道，在图 6C 中作为 IP:PGIS/WB:PGIS 印迹的第 4–6 条泳道（AMPKα2 敲除样本）使用。
已被撤回的 28 篇论文分别是：
1.Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo,Circulation Research;
2.Adenosine monophosphate-activated protein kinase-α2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation,Arteriosclerosis, Thrombosis, and Vascular Biology;
3.Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite,Arteriosclerosis, Thrombosis, and Vascular Biology;
4.Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acid,American Journal of Physiology- Endocrinology and Metabolism;
5.AMPKα2 Deletion Exacerbates Neointima Formation by Upregulating Skp2 in Vascular Smooth Muscle Cells,Circulation Research;
6.Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner,Circulation;
7.Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance，Diabetes；
8.Activation of AMP-activated protein kinase α1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and Survivin，Journal of Biological Chemistry；
9.Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells: Role of peroxynitrite，Journal of Biological Chemistry；
10.Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo : Role of mitochondrial reactive nitrogen species，Journal of Biological Chemistry；
11.Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase，Journal of Biological Chemistry；
12.Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells，Journal of Biological Chemistry；
13.Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: A role for oxidant stress，Journal of Biological Chemistry；
14.Protein kinase Cζ-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells，Journal of Biological Chemistry；
15.Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo，Journal of Biological Chemistry；
16.Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling，Journal of Biological Chemistry；
17.Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes，Journal of Molecular Endocrinology；
18.Activation of the AMP-activated protein kinase (AMPK) by nitrated lipids in endothelial cells，PLOS ONE；
19.Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5'-Triphosphate Cyclohydrolase 1 Instigate Its Ubiquitination in Diabetes，Diabetes；
20.Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation，Diabetes；
21.Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes，Diabetes；
22.Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT)，PLOS ONE；
23.Tyrosine Nitration of PA700 Links Proteasome Activation to Endothelial Dysfunction in Mouse Models with Cardiovascular Risk Factors，PLOS ONE；
24.Transcription factor Krüppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation，Cardiovascular Research；
25.Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis，Nature communications；
26.Proteasome-Dependent Degradation of Guanosine 5'-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus，Circulation；
27.Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo，Diabetes；
28.In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I，Diabetes；
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