仅供医学专业人士阅读参考
诊疗大小问题,看看指南怎么说
《新型冠状病毒感染相关性心肌炎简明诊治建议(第一版)》:
01
实验室检查
1)心肌损伤标志物:肌钙蛋白最为敏感和特异,持续性增高说明心肌持续进行性损伤和加重,提示预后不良。
2)脑钠肽(BNP)或氨基末端脑钠肽前体(NT-proBNP):正常或升高,如显著升高,提示心功能受损严重,对合并重症肺炎者有重要鉴别诊断价值。
02
心电图
1)在新冠病毒感染相关性心肌炎诊断过程中,心电图的敏感度较高,但特异度低,应进行多次检查,比较其变化。
2)所有患者均应行24h动态心电图检查。
3)心电图表现:①窦性心动过速最为常见;②频发房性早搏或室性早搏及短阵室性心动过速;③出现束支阻滞或房室传导阻滞提示预后不良;④肢体导联特别是胸前导联低电压提示心肌受损广泛且严重;⑤ST-T改变常见部分患者的心电图甚至可表现为类似急性心肌梗死的图形。
03
超声心动图
新冠病毒感染相关性心肌炎诊断和随访意义重大,建议根据病情动态观察。可见以下改变:
1)室壁运动:轻症者可正常,重症可见弥漫性室壁运动减低;
2)心脏收缩功能:轻症正常,重症可见左心室射血分数显著降低;
3)心腔大小:多数患者心腔大小正常,仅少数患者心腔稍扩大,极少数明显扩 大。
04
胸部X线或胸部CT检查
所有疑诊患者均行胸部X线检查或胸部CT检查,有阳性发现或危重患者进行动态监测。
05
冠状动脉造影
临床疑似心肌炎,但心电图有缺血、梗死改变,或年龄较大需排除急性心肌梗死的患者,应立即行冠状动脉造影。
06
心脏磁共振成像(MRI)
疑诊患者在血液动力学稳定等条件许可时可进行MRI,在出现心肌炎最初临床表现后2-3周灵敏度最高;但是鉴于MRI在心肌炎发病早期的阳性率较低,必须慎重选择。
07
经皮心内膜心肌活检
对临床疑似心肌炎的患者需考虑行心肌活检。
新冠相关心肌炎,有哪些症状?
新冠相关心肌炎,如何治疗?
新冠病毒心肌炎的发病机制是?
打开决策助手App临床指南模块,对话各大指南
国内外权威指南
决策助手“临床指南”模块都有
参考资料:
[1]Massetti GM,Jackson BR,Brooks JT,et al.Summary of guidance for
minimizing the impact of COVID-19 on individual persons,communities,and
health care systems—United States,August 2022.MMWR Morb Mortal Wkly
Rep 2022;71:1057–64
[2]Iuliano AD,Brunkard JM,Boehmer TK,et al.Trends in disease severity and
health care utilization during the early Omicron variant period compared with
previous SARS-CoV-2 high transmission periods-United States,December
2020–January 2022.MMWR Morb Mortal Wkly Rep 2022;71:146–52
[3]Centers for Disease Control and Prevention(CDC).Myocarditis and
pericarditis following mRNA COVID-19 vaccination.Accessed on 10 September
2021,https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/myocarditis.
[4]Chew NWS,Cheong C,Kong G,Phua K,Ngiam JN,Tan BYQ,et al.An AsiaPacific study on healthcare workers’perceptions of,and willingness to receive,
the COVID-19 vaccination.Int J Infect Dis 2021;106:52–60.
[5]Daniels CJ,Rajpal S,Greenshields JT,et al.Prevalence of clinical and
subclinical myocarditis in Competitive Athletes with recent SARS-CoV-2
infection:results from the big ten COVID-19 cardiac registry.JAMA Cardiol
[6]Davis,M.G.Bobba,A.Chourasia,P.et al.COVID-19 Associated Myocarditis
Clinical Outcomes among Hospitalized Patients in the United States:A
Propensity Matched Analysis of National Inpatient Sample.Viruses 2022,14,
[7]Tenforde MW,Self WH,Gaglani M,et al.;IVY Network.Effectiveness of
mRNA vaccination in preventing COVID-19–associated invasive mechanical
ventilation and death—United States,March 2021–January 2022.MMWR Morb
Mortal Wkly Rep 2022;71:459–65
[8]K.Sawalha et al.Systematic Review of COVID-19 Related Myocarditis:
Insights on Management and Outcome.Cardiovascular Revascularization
Medicine 23(2021)107–113
[9]Sozzi FB,Gherbesi E,Faggiano A,et al.Viral Myocarditis:Classification,
Diagnosis,and Clinical Implications.Front.Cardiovasc.Med.9:908663.doi:
10.3389/fcvm.2022.
[10]Teresa C,Georgios G,Gherardo F,e al.COVID-19 and myocarditis:a
systematic review and overview of current challenges.Heart Failure Reviews
(2022)27:251–261
[11]htmBasso C.Myocarditis.N Engl J Med 2022;387:1488-1500.
[12]汪道文,李晟,蒋建刚等,中华医学会心血管病学分会精准医学学组,中华
心血管病杂志编辑委员会,成人暴发性心肌炎工作组.成人暴发性心肌炎诊断与
治疗中国专家共识.中华心血管病杂志,2017,45(9):742-752
[13]Jone PN,John A,Oster ME,et al.SARS-CoV-2 infection and associated
cardiovascular manifestations and complications in children and young adults:
A scientific statement from the American Heart Association.Circulation
2022;145:e1037-e1052.
[14]Ammirati E,Lupi L,Palazzini M,et al.Prevalence,characteristics,and
outcomes of COVID-19-associated acute myocarditis.Circulation
2022;145:1123-1139.
[15]Patone M,Mei XW,Handunnetthi L,et al.Risks of myocarditis,pericarditis,
and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV2 infection.Nat Med 2022;28:410-422.
[16]Chimenti C,Magnocavallo M,Ballatore F,et al.Prevalence and clinical
implications of COVID-19 myocarditis.Card Electrophysiol Clin 2022;14:53-62.
[17]Molina-Ramos AI,Gómez-Moyano E,Rodríguez-Capitán J,et al.
Myocarditis related to COVID-19 and SARS-CoV-2 vaccination.J Clin Med
2022;11:6999.
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